ORAL VACCINATION AGAINST YERSINIA RUCKERI: OXIDATIVE STRESS BIOMARKERS IN THE GILLS OF RAINBOW TROUT (ONCORHYNCHUS MYKISS WALBAUM)

The aim of this study was to assess the effect oral vaccination against Yersinia ruckeri based on oxidative stress biomarkers in gills rainbow trout (Oncorhynchus mykiss Walbaum). vaccine consisted three Y. strains (O1 serotype) that originated from cultured different farms, where fish exhibited clinical signs enteric redmouth disease. concentrated incorporated into food; treatment delivered times at one-day intervals. Two months after immunization, were sampled. resulted non-significant changes TBARS level as lipid peroxidation marker, aldehydic and ketonic derivatives oxidatively modified proteins second month immunization ruckeri. A significant decrease superoxide dismutase activity (by 36%, p = 0.002) compared untreated controls occurred. alterations markers suggest antioxidant defenses may contribute balance between modification vaccinated We did not find any 60 days immunization. This is likely a result long-term adaptation Understanding role tissues has important implications for understanding complex physiological occur also improving aquaculture practices maximize tissue growth health trout. sensitive potentially be used evaluating toxicity From practical point view, results useful relation studies infections development, administration, uptake new vaccines applicable large amounts fish.